3rd out on appeal after a substitution—MLB

[spark2212]

Let’s say you have a runner involved in a play with two outs, and after the play is over, an offensive substitution is made. Then, the defense appeals (as on a missed base or for failing to tag) and that runner is called out to end the inning. Is the substitute burned or did managerial moves made after the third out get undone? Does this also hold for a defensive substitution?

[noumpere]

The subs are in the game; the players replaced are out (with re-entry depending on the specific code).